Release of plasmid DNA from intravascular stents coated with ultrathin multilayered polyelectrolyte films.

ABSTRACT: Materials that permit control over the release of DNA from the surfaces of topologically complex implantable devices, such as intravascular stents, could contribute to the development of new approaches to the localized delivery of DNA. We report the fabrication of ultrathin, multilayered polyelectrolyte films that permit both the immobilization and controlled release of plasmid DNA from the surfaces of stainless steel intravascular stents. Our approach makes use of an aqueous-based, layer-by-layer method for the assembly of nanostructured thin films consisting of alternating layers of plasmid DNA and a hydrolytically degradable polyamine. Characterization of coated stents using scanning electron microscopy (SEM) demonstrated that stents were coated uniformly with an ultrathin film ca. 120

SUBMITTER: Jewell CM 

PROVIDER: S-EPMC2522324 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature