Ontology highlight
ABSTRACT:
SUBMITTER: Bjorkqvist M
PROVIDER: S-EPMC2525598 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20080714 8
Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. We examined the peripheral immune system and found widespread evidence of innate immune activation detectable in plasma throughout the course of HD. Interleukin 6 levels were increased in HD gene carriers with a mean of 16 years before the predicted onset of clinical symptoms. To our knowledge, this is the earliest plasma abnormality identified in HD. Monocytes from ...[more]