Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase.

ABSTRACT: Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.

SUBMITTER: Tipparaju SK 

PROVIDER: S-EPMC2526048 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature