Ontology highlight
ABSTRACT:
SUBMITTER: Birsoy K
PROVIDER: S-EPMC2526100 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Birsoy Kivanç K Soukas Alexander A Torrens Javier J Ceccarini Giovanni G Montez Jason J Maffei Margherita M Cohen Paul P Fayzikhodjaeva Gulnorakhon G Viale Agnes A Socci Nicholas D ND Friedman Jeffrey M JM
Proceedings of the National Academy of Sciences of the United States of America 20080827 35
The cellular program responsible for the restoration of adipose tissue mass after weight loss is largely uncharacterized. Leptin mRNA levels are highly correlated with adipose tissue mass, and leptin expression can thus be used as a surrogate for changes in the amount of adipose tissue. To further study the responses of adipocytes to changes in weight, we created a transgenic mouse expressing the luciferase reporter gene under the control of leptin regulatory sequences, which allows noninvasive ...[more]