4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function.

ABSTRACT: The T box transcription antitermination system is a riboswitch found primarily in Gram-positive bacteria which monitors the aminoacylation of the cognate tRNA and regulates a variety of amino acid-related genes. Novel 4,5-disubstituted oxazolidinones were identified as high affinity RNA molecular effectors that modulate the transcription antitermination function of the T box riboswitch.

SUBMITTER: Anupam R 

PROVIDER: S-EPMC2526248 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature