Ontology highlight
ABSTRACT:
SUBMITTER: Nagarajan M
PROVIDER: S-EPMC2526314 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20061001 21
In connection with an ongoing investigation of indenoisoquinoline topoisomerase I (Top1) inhibitors as potential therapeutic agents, the pharmacophore possessing di(methoxy) and methylenedioxy substituents was held constant, and new derivatives were synthesized with nitrogen heterocycles appended to the lactam side chain. Compounds were evaluated for Top1 inhibition and for cytotoxicity in the National Cancer Institute's human cancer cell screen. Some of the more potent derivatives were also scr ...[more]