Global gene expression analysis identifies PDEF transcriptional networks regulating cell migration during cancer progression.

ABSTRACT: Prostate derived ETS factor (PDEF) is an ETS (epithelial-specific E26 transforming sequence) family member that has been identified as a potential tumor suppressor. In multiple invasive breast cancer cells, PDEF expression inhibits cell migration by preventing the acquisition of directional morphological polarity conferred by changes in cytoskeleton organization. In this study, microarray analysis was used to identify >200 human genes that displayed a common differential expression pattern in three invasive breast cancer cell lines after expression of exogenous PDEF protein. Gene ontology associations and data mining analysis identified focal adhesion, adherens junctions, cell adhesion, and actin cytoskeleton regulation as cell migration-associated interaction pathways significantly impact

SUBMITTER: Turner DP 

PROVIDER: S-EPMC2526691 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature