Dataset Information
Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity.
Ontology highlight
ABSTRACT: Context
Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed.Objective
To investigate the possibility of the existence of a crosstalk between the CALPAIN 10 homologue CALPAIN 5 and nuclear receptors of the peroxisome proliferator-activated receptors family.Design
Cross-sectional, genetic association study and gene-gene interaction analysis.Subjects
The study sample comprise 1953 individuals, 725 obese (defined as body mass index > or = 30) and 1228 non obese subjects.Results
In the monogenic analysis, only the peroxisome proliferator-activated receptor delta (PPARD) gene was associated with obesity (OR = 1.43 [1.04-1.97], p = 0.027). In addition, we have found a significant interaction between CAPN5 and PPARD genes (p = 0.038) that reduces the risk for obesity in a 55%.Conclusion
Our results suggest that CAPN5 and PPARD gene products may also interact in vivo.
SUBMITTER: Saez ME
PROVIDER: S-EPMC2527300 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Publications
Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity.
Cardiovascular diabetology 20080725
<h4>Context</h4>Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed.<h4>Objective</h4>To investigate the possibility of the existence of a crosstalk between the CALPAIN 10 homologue CALPAIN 5 and nuclear receptors of the peroxisome proliferator-activated receptors family.<h4>Design</h4>Cross-sectional, genetic association study and gene-gene interaction analysis.<h4>Subjects</h4>The ...[more]