Multiple advantageous amino acid variants in the NAT2 gene in human populations.

ABSTRACT:

Background

Genetic variation at NAT2 has been long recognized as the cause of differential ability to metabolize a wide variety of drugs of therapeutic use. Here, we explore the pattern of genetic variation in 12 human populations that significantly extend the geographic range and resolution of previous surveys, to test the hypothesis that different dietary regimens and lifestyles may explain inter-population differences in NAT2 variation.

Methodology/principal findings

The entire coding region was resequenced in 98 subjects and six polymorphic positions were genotyped in 150 additional subjects. A single previously undescribed variant was found (34T>C; 12Y>H). Several aspects of the data do not fit the expectations of a neutral model, as assessed by coalescent simulations.

SUBMITTER: Luca F 

PROVIDER: S-EPMC2527519 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature