Inhibition of cytokinesis by wiskostatin does not rely on N-WASP/Arp2/3 complex pathway.

ABSTRACT:

Background

Cytokinesis is the final step of cell division taking place at the end of mitosis during which the cytoplasmic content and replicated chromosomes of a cell are equally partitioned between the two daughter cells. This process is achieved by the formation and the ingression of an actomyosin contractile ring under the control of equatorial microtubules. The mechanisms of contractile ring formation are not fully understood but involve recruitment of preexisting actin filaments and de novo actin polymerisation.

Results

In this study, we evaluated the role of the actin nucleation factor, Arp2/3 complex, during cytokinesis. We found that the Arp2/3 complex is recruited late to the cleavage furrow suggesting a potential involvement of Arp2/3 complex during this process. F

SUBMITTER: Bompard G 

PROVIDER: S-EPMC2527559 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature