How to build transcriptional network models of mammalian pattern formation.

ABSTRACT:

Background

Genetic regulatory networks of sequence specific transcription factors underlie pattern formation in multicellular organisms. Deciphering and representing the mammalian networks is a central problem in development, neurobiology, and regenerative medicine. Transcriptional networks specify intermingled embryonic cell populations during pattern formation in the vertebrate neural tube. Each embryonic population gives rise to a distinct type of adult neuron. The homeodomain transcription factor Lbx1 is expressed in five such populations and loss of Lbx1 leads to distinct respecifications in each of the five populations.

Methodology/principal findings

We have purified normal and respecified pools of these five populations from embryos bearing one or two copies of the nu

SUBMITTER: Kioussi C 

PROVIDER: S-EPMC2527684 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature