An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs).

ABSTRACT: We report a novel resource (methylation profiles of DNA, or mPod) for human genome-wide tissue-specific DNA methylation profiles. mPod consists of three fully integrated parts, genome-wide DNA methylation reference profiles of 13 normal somatic tissues, placenta, sperm, and an immortalized cell line, a visualization tool that has been integrated with the Ensembl genome browser and a new algorithm for the analysis of immunoprecipitation-based DNA methylation profiles. We demonstrate the utility of our resource by identifying the first comprehensive genome-wide set of tissue-specific differentially methylated regions (tDMRs) that may play a role in cellular identity and the regulation of tissue-specific genome function. We also discuss the implications of our findings with respect to the reg

SUBMITTER: Rakyan VK 

PROVIDER: S-EPMC2527707 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature