Synthesis of (-)-chaetominine.

ABSTRACT: The tricyclic hydroxy imidazolidinone was converted to chaetominine in seven steps in 22% overall yield. The key step was the construction of the delta-lactam by heating an amino ester with a catalytic amount of DMAP in toluene at reflux.

SUBMITTER: Snider BB 

PROVIDER: S-EPMC2527753 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature