SNP-specific extraction of haplotype-resolved targeted genomic regions.

ABSTRACT: The availability of genotyping platforms for comprehensive genetic analysis of complex traits has resulted in a plethora of studies reporting the association of specific single-nucleotide polymorphisms (SNPs) with common diseases or drug responses. However, detailed genetic analysis of these associated regions that would correlate particular polymorphisms to phenotypes has lagged. This is primarily due to the lack of technologies that provide additional sequence information about genomic regions surrounding specific SNPs, preferably in haploid form. Enrichment methods for resequencing should have the specificity to provide DNA linked to SNPs of interest with sufficient quality to be used in a cost-effective and high-throughput manner. We describe a simple, automated method of targeting spe

SUBMITTER: Dapprich J 

PROVIDER: S-EPMC2528194 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature