Tissue-specific splicing factor gene expression signatures.

ABSTRACT: The alternative splicing code that controls and coordinates the transcriptome in complex multicellular organisms remains poorly understood. It has long been argued that regulation of alternative splicing relies on combinatorial interactions between multiple proteins, and that tissue-specific splicing decisions most likely result from differences in the concentration and/or activity of these proteins. However, large-scale data to systematically address this issue have just recently started to become available. Here we show that splicing factor gene expression signatures can be identified that reflect cell type and tissue-specific patterns of alternative splicing. We used a computational approach to analyze microarray-based gene expression profiles of splicing factors from mouse, chimpanzee

SUBMITTER: Grosso AR 

PROVIDER: S-EPMC2528195 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature