Enantioselective total synthesis of lycopodine.

ABSTRACT: The first enantioselective total synthesis of lycopodine has been completed. Key steps include a highly diastereoselective organocatalyzed cyclization of a keto sulfone to establish the key C7 and C8 stereocenters and a tandem 1,3-sulfonyl shift/intramolecular Mannich cyclization to form the tricyclic core.

SUBMITTER: Yang H 

PROVIDER: S-EPMC2528287 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature