Clinical, agricultural, and evolutionary biology of myostatin: a comparative review.

ABSTRACT: The discovery of myostatin and our introduction to the "Mighty Mouse" over a decade ago spurred both basic and applied research and impacted popular culture as well. The myostatin-null genotype produces "double muscling" in mice and livestock and was recently described in a child. The field's rapid growth is by no means surprising considering the potential benefits of enhancing muscle growth in clinical and agricultural settings. Indeed, several recent studies suggest that blocking myostatin's inhibitory effects could improve the clinical treatment of several muscle growth disorders, whereas comparative studies suggest that these actions are at least partly conserved. Thus, neutralizing myostatin's effects could also have agricultural significance. Extrapolating between studies that use di

SUBMITTER: Rodgers BD 

PROVIDER: S-EPMC2528853 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature