The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes.

ABSTRACT: The endoplasmic reticulum (ER) is the entry site into the secretory pathway for newly synthesized proteins destined for the cell surface or released into the extracellular milieu. The study of protein folding and trafficking within the ER is an extremely active area of research that has provided novel insights into many disease processes. Cells have evolved mechanisms to modulate the capacity and quality of the ER protein-folding machinery to prevent the accumulation of unfolded or misfolded proteins. These signaling pathways are collectively termed the unfolded protein response (UPR). The UPR sensors signal a transcriptional response to expand the ER folding capacity, increase degradation of malfolded proteins, and limit the rate of mRNA translation to reduce the client protein load. Rece

SUBMITTER: Scheuner D 

PROVIDER: S-EPMC2528859 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature