A functional peroxisome proliferator-activated receptor-gamma ligand-binding domain is not required for adipogenesis.

ABSTRACT: The nuclear hormone receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) is the central regulator of adipogenesis. Although it is the target for several drugs that function as agonist activators, a high affinity endogenous ligand for this receptor that is involved in regulating adipogenesis has yet to be identified. Here, we investigated the requirement for ligand activation of PPARgamma in fat cell differentiation, taking advantage of a natural mutant of this receptor that does not bind or become activated by any known natural or synthetic ligand. When ectopically expressed in PPARgamma-null fibroblasts, this Q286P allele was able to strongly promote morphological adipogenesis, without any significant difference compared with wild-type PPARgamma. In addition, no significa

SUBMITTER: Walkey CJ 

PROVIDER: S-EPMC2529017 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature