High fidelity kinetic self-sorting in multi-component systems based on guests with multiple binding epitopes.

ABSTRACT: The molecular recognition platforms of natural systems often possess multiple binding epitopes, each of which has programmed functional consequences. We report the dynamic behavior of a system comprising CB[6], CB[7], and guests cyclohexanediammonium (1) and adamantanealkylammonium (2) that we refer to as a two-faced guest because it contains two distinct binding epitopes. We find that the presence of the two-faced guest--just as is observed for protein targeting in vivo--dictates the kinetic pathway that the system follows toward equilibrium. The influence of two-faced guest structure, cation concentration, cation identity, and individual rate and equilibrium constants on the behavior of the system was explored by a combination of experiment and simulation. Deconstruction of this system l

SUBMITTER: Mukhopadhyay P 

PROVIDER: S-EPMC2529227 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature