Duration of chronic inflammation alters gene expression in muscle from untreated girls with juvenile dermatomyositis.

ABSTRACT:

Background

To evaluate the impact of the duration of chronic inflammation on gene expression in skeletal muscle biopsies (MBx) from untreated children with juvenile dermatomyositis (JDM) and identify genes and biological processes associated with the disease progression, expression profiling data from 16 girls with active symptoms of JDM greater than or equal to 2 months were compared with 3 girls with active symptoms less than 2 months.

Results

Seventy-nine genes were differentially expressed between the groups with long or short duration of untreated disease. Genes involved in immune responses and vasculature remodelling were expressed at a higher level in muscle biopsies from children with greater or equal to 2 months of symptoms, while genes involved in stress responses

SUBMITTER: Chen YW 

PROVIDER: S-EPMC2529263 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature