Interlobular and intralobular mammary stroma: genotype may not reflect phenotype.

ABSTRACT:

Background

The normal growth and function of mammary epithelial cells depend on interactions with the supportive stroma. Alterations in this communication can lead to the progression or expansion of malignant growth. The human mammary gland contains two distinctive types of fibroblasts within the stroma. The epithelial cells are surrounded by loosely connected intralobular fibroblasts, which are subsequently surrounded by the more compacted interlobular fibroblasts. The different proximity of these fibroblasts to the epithelial cells suggests distinctive functions for these two subtypes. In this report, we compared the gene expression profiles between the two stromal subtypes.

Methods

Fresh normal breast tissue was collected from reduction mammoplasty patients and immediatel

SUBMITTER: Fleming JM 

PROVIDER: S-EPMC2529294 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature