Duplications and functional divergence of ADP-glucose pyrophosphorylase genes in plants.

ABSTRACT:

Background

ADP-glucose pyrophosphorylase (AGPase), which catalyses a rate limiting step in starch synthesis, is a heterotetramer comprised of two identical large and two identical small subunits in plants. Although the large and small subunits are equally sensitive to activity-altering amino acid changes when expressed in a bacterial system, the overall rate of non-synonymous evolution is approximately 2.7-fold greater for the large subunit than for the small subunit. Herein, we examine the basis for their different rates of evolution, the number of duplications in both large and small subunit genes and document changes in the patterns of AGPase evolution over time.

Results

We found that the first duplication in the AGPase large subunit family occurred early in the history o

SUBMITTER: Georgelis N 

PROVIDER: S-EPMC2529307 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature