Integrative analysis of RUNX1 downstream pathways and target genes.

ABSTRACT:

Background

The RUNX1 transcription factor gene is frequently mutated in sporadic myeloid and lymphoid leukemia through translocation, point mutation or amplification. It is also responsible for a familial platelet disorder with predisposition to acute myeloid leukemia (FPD-AML). The disruption of the largely unknown biological pathways controlled by RUNX1 is likely to be responsible for the development of leukemia. We have used multiple microarray platforms and bioinformatic techniques to help identify these biological pathways to aid in the understanding of why RUNX1 mutations lead to leukemia.

Results

Here we report genes regulated either directly or indirectly by RUNX1 based on the study of gene expression profiles generated from 3 different human and mouse platforms. The

SUBMITTER: Michaud J 

PROVIDER: S-EPMC2529319 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature