Synthesis of xanthones, thioxanthones, and acridones by the coupling of arynes and substituted benzoates.

ABSTRACT: The reaction of silylaryl triflates, CsF, and ortho-heteroatom-substituted benzoates affords a general and efficient way to prepare biologically interesting xanthones, thioxanthones, and acridones. This chemistry presumably proceeds by a tandem intermolecular nucleophilic coupling of the benzoate with an aryne and a subsequent intramolecular electrophilic cyclization.

SUBMITTER: Zhao J 

PROVIDER: S-EPMC2529457 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature