Protein structure protection commits gene expression patterns.

ABSTRACT:

Background

Gene co-expressions often determine module-defining spatial and temporal concurrences of proteins. Yet, little effort has been devoted to tracing coordinating signals for expression correlations to the three-dimensional structures of gene products.

Results

We performed a global structure-based analysis of the yeast and human proteomes and contrasted this information against their respective transcriptome organizations obtained from comprehensive microarray data. We show that protein vulnerability quantifies dosage sensitivity for metabolic adaptation phases and tissue-specific patterns of mRNA expression, determining the extent of co-expression similarity of binding partners. The role of protein intrinsic disorder in transcriptome organization is also delineated b

SUBMITTER: Chen J 

PROVIDER: S-EPMC2530859 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature