A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis.

ABSTRACT:

Background

The difficulty in elucidating the genetic basis of complex diseases roots in the many factors that can affect the development of a disease. Some of these genetic effects may interact in complex ways, proving undetectable by current single-locus methodology.

Results

We have developed an analysis tool called Hypothesis Free Clinical Cloning (HFCC) to search for genome-wide epistasis in a case-control design. HFCC combines a relatively fast computing algorithm for genome-wide epistasis detection, with the flexibility to test a variety of different epistatic models in multi-locus combinations. HFCC has good power to detect multi-locus interactions simulated under a variety of genetic models and noise conditions. Most importantly, HFCC can accomplish exhaustive genome-

SUBMITTER: Gayan J 

PROVIDER: S-EPMC2533022 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature