Altered gene expression in highly purified enterocytes from patients with active coeliac disease.

ABSTRACT:

Background

Coeliac disease is a multifactorial inflammatory disorder of the intestine caused by ingestion of gluten in genetically susceptible individuals. Genes within the HLA-DQ locus are considered to contribute some 40% of the genetic influence on this disease. However, information on other disease causing genes is sparse. Since enterocytes are considered to play a central role in coeliac pathology, the aim of this study was to examine gene expression in a highly purified isolate of these cells taken from patients with active disease. Epithelial cells were isolated from duodenal biopsies taken from five coeliac patients with active disease and five non-coeliac control subjects. Contaminating T cells were removed by magnetic sorting. The gene expression profile of the cells was

SUBMITTER: Bracken S 

PROVIDER: S-EPMC2533024 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature