Comparison of prognostic gene expression signatures for breast cancer.

ABSTRACT:

Background

During the last years, several groups have identified prognostic gene expression signatures with apparently similar performances. However, signatures were never compared on an independent population of untreated breast cancer patients, where risk assessment was computed using the original algorithms and microarray platforms.

Results

We compared three gene expression signatures, the 70-gene, the 76-gene and the Gene expression Grade Index (GGI) signatures, in terms of predicting distant metastasis free survival (DMFS) for the individual patient. To this end, we used the previously published TRANSBIG independent validation series of node-negative untreated primary breast cancer patients. We observed agreement in prediction for 135 of 198 patients (68%) when consider

SUBMITTER: Haibe-Kains B 

PROVIDER: S-EPMC2533026 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature