The evolving transcriptome of head and neck squamous cell carcinoma: a systematic review.

ABSTRACT:

Background

Numerous studies were performed to illuminate mechanisms of tumorigenesis and metastases from gene expression profiles of Head and Neck Squamous Cell Carcinoma (HNSCC). The objective of this review is to conduct a network-based meta-analysis to identify the underlying biological signatures of the HNSCC transcriptome.

Methods and findings

We included 63 HNSCC transcriptomic studies into three specific categories of comparisons: Pre, premalignant lesions v.s. normal; TvN, primary tumors v.s. normal; and Meta, metastatic or invasive v.s. primary tumors. Reported genes extracted from the literature were systematically analyzed. Participation of differential gene activities across three progressive stages deciphered the evolving nature of HNSCC. In total, 1442 genes we

SUBMITTER: Yu YH 

PROVIDER: S-EPMC2533097 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature