Unexpected acetylcholinesterase activity of cocaine esterases.

ABSTRACT: A series of proteins with cocaine esterase ability have been shown to hydrolyze acetylcholine with similar rate enhancements. Docking studies revealed that acetylcholine binds in a similar orientation as cocaine. These results suggest that acetylcholinesterase activity may be inherent to cocaine esterases.

SUBMITTER: Rogers CJ 

PROVIDER: S-EPMC2533137 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature