Synthesis of an advanced intermediate en route to the mitomycin natural products.

ABSTRACT: [Structure: see text] An advanced intermediate in our planned synthesis of mitomycin C has been acquired in nine steps from tert-butyl glyoxylate. The aziridinyl pyrrolidine and quinone subunits are coupled regioselectively to arrive at an enamine that is prepared for C10 homologation.

SUBMITTER: Williams AL 

PROVIDER: S-EPMC2533355 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature