Frontal white matter anisotropy and antidepressant remission in late-life depression.

ABSTRACT:

Introduction

Neuroanatomic features associated with antidepressant treatment outcomes in older depressed individuals are not well established. This study used diffusion tensor imaging to examine frontal white matter structure in depressed subjects undergoing a 12-week trial of sertraline. We hypothesized that remission would be associated with higher frontal anisotropy measures, and failure to remit with lower anisotropy.

Methods

74 subjects with Major Depressive Disorder and age 60 years or older were enrolled in a twelve-week open-label trial of sertraline and completed clinical assessments and 1.5T magnetic resonance brain imaging. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured in regions of interest placed in the white matter of the

SUBMITTER: Taylor WD 

PROVIDER: S-EPMC2533397 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature