Ontology highlight
ABSTRACT:
SUBMITTER: Park TS
PROVIDER: S-EPMC2533410 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Journal of lipid research 20080530 10
Ceramide is among a number of potential lipotoxic molecules that are thought to modulate cellular energy metabolism. The heart is one of the tissues thought to become dysfunctional due to excess lipid accumulation. Dilated lipotoxic cardiomyopathy, thought to be the result of diabetes and severe obesity, has been modeled in several genetically altered mice, including animals with cardiac-specific overexpression of glycosylphosphatidylinositol (GPI)-anchored human lipoprotein lipase (LpL(GPI)). T ...[more]