Characterization of the p53 response to oncogene-induced senescence.

ABSTRACT:

Background

P53 activation can trigger various outcomes, among them reversible growth arrest or cellular senescence. It is a live debate whether these outcomes are influenced by quantitative or qualitative mechanisms. Furthermore, the relative contribution of p53 to Ras-induced senescence is also matter of controversy.

Methodology/principal findings

This study compared situations in which different signals drove senescence with increasing levels of p53 activation. The study revealed that the levels of p53 activation do not determine the outcome of the response. This is further confirmed by the clustering of transcriptional patterns into two broad groups: p53-activated or p53-inactivated, i.e., growth and cellular arrest/senescence. Furthermore, while p53-dependent transcripti

SUBMITTER: Ruiz L 

PROVIDER: S-EPMC2535567 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature