Multilocus patterns of nucleotide polymorphism and the demographic history of Populus tremula.

ABSTRACT: I have studied nucleotide polymorphism and linkage disequilibrium using multilocus data from 77 fragments, with an average length of fragments of 550 bp, in the deciduous tree Populus tremula (Salicaceae). The frequency spectrum across loci showed a modest excess of mutations segregating at low frequency and a marked excess of high-frequency derived mutations at silent sites, relative to neutral expectations. These excesses were also seen at replacement sites, but were not so pronounced for high-frequency derived mutations. There was a marked excess of low-frequency mutations at replacement sites, likely indicating deleterious amino acid-changing mutations that segregate at low frequencies in P. tremula. I used approximate Bayesian computation (ABC) to evaluate a number of different demogr

SUBMITTER: Ingvarsson PK 

PROVIDER: S-EPMC2535685 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature