Effects of spatially varying selection on nucleotide diversity and linkage disequilibrium: insights from deer mouse globin genes.

ABSTRACT: An important goal of population genetics is to elucidate the effects of natural selection on patterns of DNA sequence variation. Here we report results of a study to assess the joint effects of selection, recombination, and gene flow in shaping patterns of nucleotide variation at genes involved in local adaptation. We first describe a new summary statistic, Z(g), that measures the between-sample component of linkage disequilibrium (LD). We then report results of a multilocus survey of nucleotide diversity and LD between high- and low-altitude populations of deer mice, Peromyscus maniculatus. The multilocus survey included two closely linked alpha-globin genes, HBA-T1 and HBA-T2, that underlie adaptation to different elevational zones. The primary goals were to assess whether the alpha-glob

SUBMITTER: Storz JF 

PROVIDER: S-EPMC2535688 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature