Direct asymmetric Zn-aldol reaction of methyl vinyl ketone and its synthetic applications.

ABSTRACT: A direct catalytic asymmetric aldol reaction of methyl vinyl ketone is described using our dinuclear zinc catalyst. The obtained aldol adduct functions as a bifunctional building block by utilization of the vinyl functionality. For example, convergent fragment coupling methods have been demonstrated via highly diastereoselective cycloaddition of nitrile oxide after reduction into 1,3-diol or via cross-metathesis reaction.

SUBMITTER: Trost BM 

PROVIDER: S-EPMC2535804 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature