One-flask synthesis of dinucleoside tetra- and pentaphosphates.

ABSTRACT: [reaction: see text] We report a one-flask route for the synthesis of dinucleoside tetra- and pentaphosphates, in isolated yields of 50-85%. This route relies on a mixture of P(III) and P(V) chemistries, using phosphitylation of a protected nucleoside with 2-chloro-4H-l,3,2-benzo-dioxaphosphorin-4-one (salicylchlorophosphite), followed by sequential reaction with inorganic pyrophosphate and a nucleoside 5' mono- or diphosphate.

SUBMITTER: Han Q 

PROVIDER: S-EPMC2535934 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature