Estrogen receptor-mediated neuroprotection: The role of the Alzheimer's disease-related gene seladin-1.

ABSTRACT: Experimental evidence supports a protective role of estrogen in the brain. According to the fact that Alzheimer's disease (AD) is more common in postmenopausal women, estrogen treatment has been proposed. However, there is no general consensus on the beneficial effect of estrogen or selective estrogen receptor modulators in preventing or treating AD. It has to be said that several factors may markedly affect the efficacy of the treatment. A few years ago, the seladin-1 gene (for selective Alzheimer's disease indicator-1) has been isolated and found to be down-regulated in brain regions affected by AD. Seladin-1 has been found to be identical to the gene encoding the enzyme 3-beta-hydroxysterol delta-24-reductase, involved in the cholesterol biosynthetic pathway, which confers protection ag

SUBMITTER: Peri A 

PROVIDER: S-EPMC2536547 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature