Asymmetric synthesis of trans-2,5-disubstituted pyrrolidines from enantiopure homoallylic amines. Synthesis of pyrrolidine (-)-197B.

ABSTRACT: Iodocyclization of sulfinimine-derived enantiopure homoallylic sulfonamides affords trans-2,5-disubstituted 3-iodopyrrolidines and represents valuable methodology for the asymmetric synthesis of this important heterocyclic ring system.

SUBMITTER: Davis FA 

PROVIDER: S-EPMC2536609 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature