Multiple actions of lysophosphatidic acid on fibroblasts revealed by transcriptional profiling.

ABSTRACT:

Background

Lysophosphatidic acid (LPA) is a lipid mediator that acts through specific G protein-coupled receptors to stimulate the proliferation, migration and survival of many cell types. LPA signaling has been implicated in development, wound healing and cancer. While LPA signaling pathways have been studied extensively, it remains unknown how LPA affects global gene expression in its target cells.

Results

We have examined the temporal program of global gene expression in quiescent mouse embryonic fibroblasts stimulated with LPA using 32 k oligonucleotide microarrays. In addition to genes involved in growth stimulation and cytoskeletal reorganization, LPA induced many genes that encode secreted factors, including chemokines, growth factors, cytokines, pro-angiogenic and pr

SUBMITTER: Stortelers C 

PROVIDER: S-EPMC2536681 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature