Resistance to diet-induced obesity in mice with a single substituted chromosome.

ABSTRACT: Obesity and its comorbidities are taking an increasing toll on human health. Key pathways that were identified with single gene variants in humans and model organisms have led to improved understanding and treatment of rare cases of human obesity. However, similar progress remains elusive for the more common multifactorial cases of metabolic dysfunction and disease. A survey of mouse chromosome substitution strains (CSSs) provided insight into the complex genetic control of diet-induced obesity and related conditions. We now report a survey of 60 traits related to obesity and metabolic syndrome in mice with a single substituted chromosome as well as selected traits measured in congenic strains derived from the substituted strain. We found that each strain that was resistant to diet-induced

SUBMITTER: Buchner DA 

PROVIDER: S-EPMC2536825 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature