Ancient and modern duplication events and the evolution of stearoyl-CoA desaturases in teleost fishes.

ABSTRACT: Stearoyl-CoA desaturases (SCDs) are key enzymes of fatty acid biosynthesis whose regulation underpins responses to dietary, thermal, and hormonal treatment. Although two isoforms are known to exist in the common carp and human and four in mouse, there is no coherent view on how this gene family evolved to generate functionally diverse members. Here we identify numerous new SCD homologs in teleost fishes, using sequence data from expressed sequence tag (EST) and cDNA collections and genomic model species. Phylogenetic analyses of the deduced coding sequences produced only partially resolved molecular trees. The multiple SCD isoforms were, however, consistent with having arisen by an ancient gene duplication event in teleost fishes together with a more recent duplication in the tetraploid ca

SUBMITTER: Evans H 

PROVIDER: S-EPMC2536826 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature