Hydrogen bond catalyzed enantioselective vinylogous Mukaiyama aldol reaction.

ABSTRACT: [chemical reaction: see text]. The concept of hydrogen bonding catalysis was extended to the vinylogous Mukaiyama aldol reaction, which gives rapid access to polyketide derivatives. The reaction of the silyldienol ether shown and a range of aldehydes catalyzed by TADDOL proceeds regiospecifically to produce the addition products in good yields and enantiomeric excesses.

SUBMITTER: Gondi VB 

PROVIDER: S-EPMC2537470 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature