Total synthesis of amphidinolide E.

ABSTRACT: A convergent and highly stereocontrolled synthesis of amphidinolide E (1) has been accomplished. The synthesis features a highly diastereoselective (>20:1) BF3.Et2O promoted [3+2] annulation reaction between aldehyde 3 and allylsilane 4 to afford substituted tetrahydrofuran 2.

SUBMITTER: Va P 

PROVIDER: S-EPMC2538580 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature