The Met receptor tyrosine kinase prevents zebrafish primary motoneurons from expressing an incorrect neurotransmitter.

ABSTRACT:

Background

Expression of correct neurotransmitters is crucial for normal nervous system function. How neurotransmitter expression is regulated is not well-understood; however, previous studies provide evidence that both environmental signals and intrinsic differentiation programs are involved. One environmental signal known to regulate neurotransmitter expression in vertebrate motoneurons is Hepatocyte growth factor, which acts through the Met receptor tyrosine kinase and also affects other aspects of motoneuron differentiation, including axonal extension. Here we test the role of Met in development of motoneurons in embryonic zebrafish.

Results

We found that met is expressed in all early developing, individually identified primary motoneurons and in at least some later deve

SUBMITTER: Tallafuss A 

PROVIDER: S-EPMC2542365 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature