Identification and functional analysis of antifungal immune response genes in Drosophila.

ABSTRACT: Essential aspects of the innate immune response to microbial infection appear to be conserved between insects and mammals. Although signaling pathways that activate NF-kappaB during innate immune responses to various microorganisms have been studied in detail, regulatory mechanisms that control other immune responses to fungal infection require further investigation. To identify new Drosophila genes involved in antifungal immune responses, we selected genes known to be differentially regulated in SL2 cells by microbial cell wall components and tested their roles in antifungal defense using mutant flies. From 130 mutant lines, sixteen mutants exhibited increased sensitivity to fungal infection. Examination of their effects on defense against various types of bacteria and fungi revealed nine

SUBMITTER: Jin LH 

PROVIDER: S-EPMC2542415 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature