Intersession variability in single-breath diffusing capacity in diabetics without overt lung disease.

ABSTRACT:

Rationale

American Thoracic Society guidelines state that a 10% or greater intersession change in diffusing capacity of the lung (DL(CO)) should be considered clinically significant. However, little is known about the short-term intersession variability in DL(CO) in untrained subjects or how variability is affected by rigorous external quality control.

Objectives

To characterize the intersession variability of DL(CO) and the effect of different quality control methods in untrained individuals without significant lung disease.

Methods

Data were pooled from the comparator arms of 14 preregistration trials of inhaled insulin that included nonsmoking diabetic patients without significant lung disease. A total of 699 participants performed repeated DL(CO) measurements usin

SUBMITTER: Drummond MB 

PROVIDER: S-EPMC2542422 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature