Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history.

ABSTRACT:

Rationale

Airway responsiveness is a prognostic marker for asthma symptoms in later life.

Objectives

To evaluate characteristics responsible for persistence of airway responsiveness in children with asthma.

Methods

A total of 1,041 children, initially aged 5-12 years, with mild to moderate persistent asthma enrolled in the Childhood Asthma Management Program (CAMP) were studied prospectively for 8.6 +/- 1.8 years with methacholine challenges yearly.

Measurements and main results

Least squares geometric mean models were fit to determine effects of sex and age on airway responsiveness (provocative concentration producing 20% decrease in FEV(1) [PC(20)]). Multiple linear regression analysis was performed to determine factors at baseline and over time, which were a

SUBMITTER: Tantisira KG 

PROVIDER: S-EPMC2542438 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature